Furthermore SART3 has also been shown to bind to USP4, a close homologue of USP15. In addition to this histone chaperone activity, SART3 primarily functions by mediating the re annealing of the U4 and U6 snRNPs to facilitate consequent rounds of splicing in addition to its implication in several disease states including numerous cancer types and HIV through interactions with various cellular proteins.In this thesis ITC, ESI MS, analytical size exclusion, X ray crystallography, SAXS and pull down assays are used to characterise the interaction between USP15 and SART3, solve the structure of the N terminus of SART3 and identify novel binding partners of the USP15 SART3 complex. The structure of SART3’s N terminus (residues 96 574) has been solved to 3.04, revealing that it is a homodimer comprised of a series of anti parallel helices that form a shape reminiscent of a bowtie.
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