The adult mammalian kidney forms from the reciprocal interaction between two tissues; the ureteric bud which will form the collecting duct system and the metanephric mesenchyme which will form all the cells in the nephrons. This thesis used ex vivo embryonic kidney culture to show that during mouse kidney development metanephric mesenchymal cells migrated towards the periphery of the kidney. When this migration is pharmacologically inhibited the Six2 expressing metanephric mesenchyme cells no longer expanded their population and kidney development ceases.
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